Determination of Chloramphenicol. I

Liquid-chromatographic determination of cephalosporins and chloramphenicol in serum.

A "high-performance" liquid-chromatographic technique involving a radial compression module is used for measuring chloramphenicol and five cephalosporin antibiotics: cefotaxime, cefoxitin, cephapirin, and cefamandol. Serum proteins are precipitated with acetonitrile solution containing 4'-nitroacetanilide as the internal standard. The drugs are eluted with a mobile phase of methanol/acetate buf...

Voltammetric Determination of Chloramphenicol at Electrochemically Pretreated Glassy Carbon Electrode

A sensitive square wave voltammetric method for the determination of chloramphenicol (CAP) was developed using electrochemically pretreated glassy carbon electrode (EPGCE). Electrochemical pretreatment of the electrode greatly enhanced the reduction peak current (Ip) of CAP. The electrochemical investigation of CAP was carried out by using cyclic and square wave voltammetry techniques. CAP show...

Determination of Chloramphenicol in Tablets by Electrogenerated Chemiluminescence

O antibiótico cloranfenicol foi determinado em drágeas por quimiluminescência eletrogerada acoplada a sistemas FIA utilizando-se como espécie luminescente o complexo Ru(bipi) 3 . O cloranfenicol provoca um decréscimo na intensidade luminescente do complexo de rutênio que é proporcional à concentração sendo linear entre 5 x 10 e 1 x 10 mol L. Para 12 medidas sucessivas o desvio padrão relativo o...

Chloramphenicol determination in milk by liquid chromatography – tandem mass spectrometry

A high-performance liquid chromatography – tandem mass spectrometry (HPLC– MS–MS) method was developed for the determination of chloramphenicol (CAP) in milk products. Mass spectral acquisition was done using electrospray ionization in the negative ion mode applying multiple reaction monitoring of two diagnostic transition reactions for CAP (m/z 321→152 and m/z 321→257). Milk samples were extra...

Chloramphenicol.